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KMID : 0363220070450040338
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Korean Journal of Dermatology
2007 Volume.45 No. 4 p.338 ~ p.344
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5% Imiquimod Cream in the Treatment of Bowen’s Disease
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Lee Kyung-Real
Yoon Moon-Soo
Kim Doo-Hwan
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Abstract
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Background: Bowen’s disease is a challenging condition to treat because lesions often affect the elderly who are usually intolerable to invasive treatment modalities and lesions are often located at sites that heal poorly.
Objective: The aim of this study was to evaluate the effectiveness and the safety of 5% imiquimod cream for the treatment of Bowen’s disease.
Methods: Eleven patients with biopsy-proven Bowen’s disease were treated with once-daily or twice-daily self- application of 5% imiquimod cream for a maximum of 16 weeks.
Results: Nine of ten (90%) patients who completed the treatment schedule showed complete clinicopathologic regression. One (11%) patient showed recurrence of Bowen’s disease on the treated site. 5% imiquimod cream was generally well-tolerated and no serious side effects were observed.
Conclusion: 5% imiquimod cream appears to be an effective modality for treatment of Bowen’s disease and might represent a valuable alternative to surgery or other invasive treatment methods.
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KEYWORD
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Bowen’s Disease, Imiquimod
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